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KMID : 0881720170320030228
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Journal of Food Hygiene and Safety
2017 Volume.32 No. 3 p.228 ~ p.233
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Mutagenicity Study of Purified Bee Venom (Apis mellifera L.) by the Bacterial Reverse Mutation Assay
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Han Sang-Mi
Hong In-Pyo
Woo Soon-Ok
Kim Se-Gun
Jang Hye-Ri
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Abstract
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The aim of the current study was to examine genotoxicological safety of purified bee venom (Apis mellifera L.) The bacterial reverse mutation in Salmonella typhimurium (TA100, TA1535, TA98, and TA1537) and Escherichia coli (WP2 uvrA) were evaluated with purified bee venom at concentrations of 0, 1.5, 5, 15, 50, 150, and 500 μg/plate. Purified bee venom was negative in Ames test with both in the presence and absence of rat liver microsomal enzyme. According to these results, we concluded that purified bee venom did not cause bacterial reverse mutation. The safety of the purified bee venom at practical doses needs to be further evaluated in in vivo genotoxicity assays.
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KEYWORD
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Apis mellifera , Honeybee Venom , Mutagenicity , Toxicity
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